Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury
نویسندگان
چکیده
منابع مشابه
Establishment of a rat model of radiation-induced lung injury
Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....
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METABOLOMICS IS A RAPIDLY expanding new field of -omics that is gaining attention in numerous areas of biomedical research. It is a novel approach that generates a “snapshot” of all small-molecule chemicals and metabolites that are present in selected compartments in the body, and provides a viable alternative to genomics, transcriptomics, and proteomics. Metabolite detection and quantification...
متن کاملRadiation-induced Lung Injury
membrane, and are just wide enough to allow the passage of red blood cells, one cell at a time. The alveoli are lined with specialized epithelial cells termed Type I pneumocytes. Interspersed among these cells are surfactant-producing Type II pneumocytes. Within the alveolar wall, pneumocytes are separated from endothelial cells by their associated basement membranes and a potential stromal spa...
متن کاملestablishment of a rat model of radiation-induced lung injury
background: radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. materials and methods: 50 female wistar rats were randomly divided into 5 groups, average 10 rats/cage: a. control group b. 3gy×10f c. 6gy×5f d. 12.5gy×1f e.15.3gy×1f. by different doses of r...
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Background & Objective: Lung is a radiosensitive organ. Patients who are undergoing radiation therapy in their chest are subjected to radiation pneumonitis in the early phase and pulmonary fibrosis in the late one. Melatonin scavenges free radicals directly and acts as an indirect antioxidant through the activation of major antioxidant enzymes as well. The aim of the study thus is to investiga...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2017
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-017-2200-9